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up an osmotic gradient that favors the parallel movement of water The proximal tubule epithelium is very permeable to water, and water a substantial amount indeed follows solute from the lumen to the interstitium The water moves in equal proportions as solute, so that both the fluid removed from the lumen and that remaining behind are essentially iso-osmotic with the original filtrate (ie, have the same osmolality) We say essentially because there must be some difference in osmolality to induce water movement, but for an epithelial barrier (like the proximal tubule) that is very permeable to water, a difference of less than 1 mOsm/kg is sufficient to drive reabsorption of water Tubular hydrostatic pressure is several millimeters of mercury greater than interstitial hydrostatic pressure, and this pressure gradient also favors reabsorption However, under normal circumstances, this is a small influence It requires a hydrostatic pressure gradient of 193 mm Hg to act as a driving force equivalent to an osmotic gradient of 1 mOsm/kg, and the hydrostatic pressure difference is usually not more than 5 8 mm Hg Once in the interstitium, the solutes and water move from interstitium into the peritubular capillaries and are returned to the systemic circulation Otherwise, the kidney would swell without limit Fortunately, the Starling forces across the peritubular capillaries favor reabsorption The capillary hydraulic pressure, which was about 60 mm Hg in the glomerular capillaries, and opposes uptake of interstitial fluids has fallen to about 15 20 mm Hg within the peritubular capillaries, but the plasma oncotic pressure, resulting from filtration in the glomerular capillaries, has risen to more than 30 mm Hg There is a small but significant, interstitial pressure (Table 4 1) Therefore, the net filtration pressure is now a net absorptive pressure, and net fluid movement is into the peritubular capillaries The alert student can appreciate the fact that if cortical Starling forces are abnormal (eg, low plasma oncotic pressure as when liver disease prevents normal production of serum albumin), absorption of fluid from the cortical interstitium can be slowed, causing a backup of fluid that inhibits fluid movement from tubular lumen to interstitium Ultimately, this can lead to increased excretion of water and electrolytes from the body As blood flows through the peritubular capillaries, there is a rapid diffusion of individual molecules back and forth between capillary plasma and cortical interstitial fluid The total volume of interstitial space is only 4% of the total cortical volume, and the vascular volume is a little higher Given the very high renal blood flow, the solute concentrations in the interstitial fluid are essentially clamped to those in the blood perfusing the cortex The cortical interstitium remains quite plasma-like (minus the proteins) in its composition, even though large amounts of solute continuously cross through the interstitium from tubule to blood With all of these factors as a background, let us more closely examine how things are reabsorbed We can take an anthropomorphic view and ask, If I m a molecule in the lumen, what induces me to go across the epithelial layer instead of just staying where I am.

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How To Generate Barcode And Read The Barcode In MVC
May 29, 2018 · In this article, I explain how to generate Barcode and after that how to read the bar code. First we need to know what bar code is.

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As shown in figure 3.4, SharePoint projects have a special tab for configuring the deployment configuration. Visual Studio 2010 comes with two configurations out of the box:

Default Retracts the old solution, adds the new one, and activates the Features. No Activation Retracts the old solution and adds the new one without activating the Features.

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