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Because of the importance of glucose as the basic coin of cellular energy exchange and the prevalence of diabetes, which manifests itself as renal disease along with other pathologies, we review the normal renal handling of glucose The normal plasma glucose level is about 90 mg/dL (5 mmol/L) It rises transiently to well over 100 mg/dL during meals and can reach levels of over 1000 mg/dL (over 55 mmol/L) in severe diabetes Normally, all the filtered glucose is reabsorbed in the proximal tubule This involves removing glucose from the tubular lumen along with sodium via a sodium-dependent glucose symporter (SGLUT) across the apical membrane of proximal convoluted tubule epithelial cells, followed by its exit across the basolateral membrane into the interstitium via a GLUT uniporter Unlike the case for sodium and many other solutes discussed later, the tight junctions are not significantly permeable to glucose Therefore, as glucose is removed from the lumen and the luminal concentration falls, there is no back-leak The transport of a solute with no back-leak depends only on the characteristics of the rate-limiting transporter, in this case the SGLT symporter, and is a Tm-limited system Because glucose reabsorption is a Tm system, abnormally high filtered loads overwhelm the reabsorptive capacity (exceed the Tm; Figure 5 1) This occurs when plasma glucose rises above roughly 300 mg/dL Again, this is a pathological situation but one that is relatively common Assume that the glucose Tm is 375 mg/min (a typical value) The normal filtered load is well below this level With a glomerular filtration rate (GFR) of 125 mL/min (125 dL/min) and plasma glucose of 90 mg/dL, the filtered load is 125 dL/min 3 90 mg/dL 5 1125 mg/min, much less than the Tm of 375 mg/min When plasma glucose reaches 300 mg/dL, the filtered load is now 125 dL/min 3 300 mg/dL 5 375 mg/min At this point, the proximal convoluted tubule fails to reabsorb all the filtered glucose, and a little glucose begins to spill into the urine Further increases in plasma glucose above 300 mg/dL lead to progressively greater renal losses We discuss the various reasons for the diuresis (high urine volume) associated with diabetes later, but one can appreciate that any glucose not reabsorbed is an osmole in the tubule that has consequences for water reabsorption. asp.net ean 13 EAN - 13 ASP . NET Control - EAN - 13 barcode generator with free ...
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19 Apr 2005 ... NET 2005 - 7.40 Kb ... The EAN - 13 barcode is composed of 13 digits, which are made up of the following sections: the first 2 or 3 digits are the ... <asp:TextBox ID= TextBox1 runat= server Width= 60px ></asp:TextBox> <asp:RegularExpressionValidator ID= RegularExpressionValidator1 runat= server ErrorMessage= Only integers allowed ControlToValidate= TextBox1 ValidationExpression= \d+ Display= Dynamic > </asp:RegularExpressionValidator> <asp:RequiredFieldValidator ID= RequiredFieldValidator1 runat= server ErrorMessage= A value is required ControlToValidate= TextBox1 Display= Dynamic > </asp:RequiredFieldValidator> 66 / 5 First, you add the text box B and set a smaller width than the default. Then you add two validators: the first uses a regular expression C to make sure it s one or more digits, and the second makes sure that the text box has a value. Both of the validators have the Display property set to Dynamic, which ensures the validator appears only when invalid. After creating the control interface, you need to make some adjustments in the codebehind. You should specify which validator group to use so that you can get the value from the text box. The following listing shows the code you add to the user control. Activity Frequency: protected override void OnInit(EventArgs e) { TextBox1.Style.Add( text-align , right ); base.OnInit(e); } public string ValidationGroup { get; set; } public int Value { get { return int.Parse(TextBox1.Text); } set { asp.net ean 13 .NET EAN 13 Generator for C#, ASP . NET , VB.NET | Generating ...
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NET Core Barcode is a cross-platform Portable Class Library that generates barcodes using barcode fonts. It supports Windows, macOS and Linux, and can be ... Working with servers often requires you to have administrative access rights to them The access granted to Windows Server 2003 administrators is powerful indeed because it allows for complete control of a machine at the local level, a domain at the domain level, or a forest at the enterprise level These rights must be used with care and consideration, especially because anything executing within an administrative context will automatically have all rights on a machine TextBox1.Text = value.ToString(); } } Plasma glucose (mg/dL) protected override void OnPreRender(EventArgs e) { RegularExpressionValidator1.ValidationGroup = this.ValidationGroup; RequiredFieldValidator1.ValidationGroup = this.ValidationGroup; TextBox1.ValidationGroup = this.ValidationGroup; base.OnPreRender(e); } Because of the risk they pose to your enterprise, administrative accounts should both be renamed from the default and should have strong complex passwords, usually of more than 15 characters Ultimately, they should be linked to smart cards for additional security asp.net ean 13 EAN - 13 Barcode Generator for ASP . NET Web Application
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