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The 2 kidneys lie outside the peritoneal cavity close to the posterior abdominal wall, 1 on each side of the vertebral column Each of the 2 kidneys is a beanshaped structure The rounded, outer convex surface of each kidney faces the side of the body, and the indented surface, called the hilum, is medial Each hilum is penetrated by a renal artery, renal vein, nerves, and a ureter, which carries urine out of the kidney to the bladder Each ureter within a kidney is formed from funnel-like structures called major calyces, which, in turn, are formed from minor calyces The minor calyces fit over underlying cone-shaped renal tissue called pyramids The tip of each pyramid is called a papilla and projects into a minor calyx The calyces act as collecting cups for the urine formed by the renal tissue in the pyramids The pyramids are arranged radially around the hilum, with the papillae pointing toward the hilum and the broad bases of the pyramids facing the outside, top, and bottom of the kidney (from the 12-o clock to the 6-o clock position) The pyramids constitute the medulla of the kidney Overlying the medullary tissue is a cortex, and covering the cortical tissue on the very external surface of the kidney is a thin connective tissue capsule (Figure 1 1) The working tissue mass of both the cortex and medulla is constructed almost entirely of tubules (nephrons and collecting tubules) and blood vessels (capillaries and capillary-like vessels) Tubules and blood vessels are intertwined (something like a plateful of spaghetti) or arranged in parallel arrays (like bundles of soda straws) and, in either case, are always close to each other Between the tubules and blood vessels lies an interstitium, which comprises less than 10% of the renal volume The interstitium contains fluid and scattered interstitial cells (fibroblasts and others) that synthesize an extracellular matrix of collagen, proteoglycans, and glycoproteins The cortex and medulla have very different properties both structurally and functionally On closer examination, we see that (1) the cortex has a highly granular appearance, absent in the medulla, and (2) each medullary pyramid is divisible into an outer zone (adjacent to the cortex) and an inner zone, which includes the papilla All these distinctions reflect the arrangement of the various tubules and blood vessels.

Figure 4.1 A Web Part has many events that are always performed in a specific order. Each event has its own purpose and should be used accordingly.

TIP DFS depends heavily on the Remote Procedure Call service Make sure this service is up and running Also, domain-based DFS roots must have synchronized clocks (to support replication and location of the root targets) Make sure all systems are synchronized with the PDC Emulator (this is normally the default in an Active Directory domain)

final adjustments before the Web Part is rendered. The SaveViewState method allows you to hook into the view state of the object and customize the view state if you want. The view state is only loaded on postbacks (which you ll see later when we go through the postback event flow). Later in this chapter, I m going to show you how to use the view state. Notice that, before the SaveViewState method is invoked on all Web Parts, the Web Part Manager will create all Web Parts on the page that are closed and invoke their constructor. This means that, even though the Web Part is closed, its constructor will be called. Avoid placing calculations or other resource-consuming operations in the constructor of the Web Part because they can be performance killers. RenderControl calls the appropriate render methods and must never be overridden. This method ensures that the control is rendered through control adapters (which you ll learn about in chapter 12). RenderControl calls the Render method,

reNaL FUNCtIONS, aNatOMY, aND BaSIC prOCeSSeS / 5

which draws the chrome of the Web Part and then calls the RenderContents method. You shouldn t override the Render method either because that method verifies that the Web Part connections are valid and, if they aren t, the method renders an error message. If you need to overwrite any of the render methods, you should override RenderContents to start with. There are scenarios when you need to override the Render method for instance, if you have to inject code or handle errors late in the event flow. Web Part Returning to the event flow, the next Constructor called event is the OnUnload method, which you can use to do any cleanup. Finally, the DisProper es set pose method is invoked. Note that all these event methods are for OnInit the ASP.NET-based Web Part. If you create a Web Part based on the SharePoint impleTrackViewState mentation, the event flow is the same except for the rendering methods. LoadViewState All events are executed in sequence for all Ordering CreateChildControls Web Parts and controls in the order in which changed compared they re added to the zones. For example, all to normal OnLoad OnLoad methods are executed on all Web Parts ow before any calls to CreateChildControls. Postback events When you re exporting a Web Part, the export file is generated just before the Web OnPreRender Part is rendered and after the personalization state is saved by the Web Part Manager. The Closed Web Parts created Web Part Manager retrieves all properties of the Web Part and creates the XML file, which SaveViewState is returned to the client.

The DFS console can also be used to modify the DFS configuration, add new targets, add new links, configure replication and so on Stand-alone DFS roots tend to be applied more often in server clusters If you use server clusters and stand-alone

The event flow is different when you re doing a postback, such as a response to a button click. A postback is a technique used by ASP.NET pages to post back data to themselves and to retain all control values. Figure 4.2 shows the event flow for a postback. The events following the TrackViewState until the SaveViewState are different compared with a normal page load. First, the LoadViewState method is called if the Web Part has any saved view states. Following that is the CreateChildControls method before the OnLoad method (the opposite order

Reabsorption is a 2-step process: lumen to interstitium, and interstitium to peritubular capillary Flux from lumen to interstitium can be transcellular, using separate transport steps in the apical and basolateral membranes, or paracellular, around the cells through tight junctions Channels and transporters promote the transmembrane flux of solutes that cannot permeate lipid bilayers Osmotic gradients drive a volume flux across membranes and epithelia